98% Esculin | Cortex Fraxini (Fraxinus Bark) Extract Pharmacopoeia-Grade High-Purity Crystalline Powder
98% High Purity Esculin | Pharmaceutical Monomer Extracted from Ash Bark (Fraxini Cortex)
- Packaging: 1kg light-proof vacuum foil bag, 25kg fiber drum with double PE liner, private label OEM repacking supported
- Attached Documents Per Batch: COA, HPLC chromatogram, MSDS, heavy metal & microbial test reports
- Product Name: Esculin (Alias: Aesculin, Horse Chestnut Extract Glycoside)
- Common Name: Esculin / Aesculin
- Latin Raw Material: Fraxinus rhynchophylla Hance (Official Cortex Fraxini of Chinese Pharmacopoeia)
- CAS No.: 531-75-9
- Core Active Monomer: Esculin (Signature coumarin active ingredient)
- Standard Assay: ≥98% (Tested by RP-HPLC Pharmacopoeia Method)
- Raw Source: Dried standardized Cortex Fraxini from Qinling Mountains authentic planting base
- Appearance: Off-white to pale beige acicular crystalline powder, odorless, free of visible impurities
- Solubility: Freely soluble in hot water, methanol, ethanol, propylene glycol; slightly soluble in cold water; insoluble in oil and petroleum ether
- Extraction & Purification Process: Warm water leaching → ethanol enrichment → macroporous resin impurity removal → preparative chromatography deep purification → low-temperature vacuum recrystallization
- Test Standards: CP, USP, EP coumarin content determination specifications
- Product Grades: Pharmaceutical Grade, Cosmetic UV Protection Grade, Research Reference Grade
- International Certifications: ISO22000, FSSC22000, full SGS testing, strict control over heavy metals & pesticide residues
- Mesh Size: 80–120 mesh, customized ultra-fine 300 mesh available
- MOQ: 1 KG
- Free Sample: 5–30g for formula trial and third-party full pharmacopoeia testing
- Shelf Life: 24 months under sealed storage at 2–8℃, avoid light oxidation & discoloration
Detailed Introduction of Esculin
Esculin (Aesculin) is the core coumarin glycoside monomer in Cortex Fraxini, a high-demand high-purity botanical raw material for pharmaceutical, sunscreen cosmetic and pharmacological research industries worldwide. We adopt traceable standardized Cortex Fraxini from Qinling Mountains, integrated mild water-alcohol dual-phase extraction and chromatography recrystallization purification technology to produce 98% stable pure esculin crystals. Interfering impurities including aesculetin, resin and tannin are completely separated, batch content fluctuation is controlled within 0.5%, fully meeting strict standards for global pharmaceutical registration, premium sunscreen formulas and university pharmacological calibration.
This monomer features unique broad-spectrum UVA/UVB ultraviolet absorption capacity, coupled with powerful anti-inflammatory, antioxidant and microcirculation-improving pharmacological properties, with clear differentiated application scenarios: In pharmaceuticals, it is applied for venous soothing preparations and heat-clearing anti-inflammatory TCM raw materials; in cosmetics, it acts as natural plant UV booster and core active for redness-repair serums; in laboratories, it serves as official pharmacopoeia reference standard for coumarin quantification and new drug screening research.
The whole closed-loop production line runs under low light and low temperature to prevent light-induced decomposition and yellowing of esculin. Pesticide residues, heavy metals and residual solvents all meet EU & US raw material import limits. It is compatible with all dosage forms including water-based oral liquids, serums, tablets and lyophilized powder, and can be compounded synergistically with flavonoids such as glycyrrhizic acid, asiaticoside and rutin. We provide stable ton-level bulk stock, customized grading and full export compliance technical service for global pharmaceutical manufacturers, cosmetic raw material traders and research institutes.
Antibacterial & Heat-Clearing Pharmacological Activity:
Inhibit multiple skin and intestinal pathogenic bacteria for internal & external anti-inflammatory preparations
Core Efficacy of Esculin
Broad-Spectrum UV Absorption Protection:
Naturally absorb UVA & UVB rays, act as botanical UV booster to reduce UV oxidative damage
Powerful Anti-Inflammatory & Anti-Redness:
Inhibit inflammatory cytokines to relieve redness, heat and stinging of skin & mucous membrane
Boost Microcirculation & Relieve Venous Discomfort:
Accelerate subcutaneous blood flow, soothe soreness and redness caused by venous stasis
Endogenous Antioxidant & Free Radical Scavenger:
Neutralize reactive oxygen species to alleviate cell damage from photoaging and oxidative stress
Standard Pharmacopoeia Calibration Substance:
98% high-purity without miscellaneous peaks, reference monomer for coumarin quantitative lab testing
Core Advantages of Esculin
98% Pharmacopoeia-Grade Pure Monomer:
Recrystallization chromatography, ultra-low miscellaneous coumarin, single pure HPLC peak without interference
Traceable Authentic Qinling Cortex Fraxini Raw Material:
Self-owned standardized planting base with higher native esculin content
Closed-Loop Low-Light Low-Temp Production:
Full light isolation, finished product stable without decomposition or discoloration during long storage
High Compatibility for Dual Industry Formulations:
Water & alcohol soluble, suitable for both oral pharmaceutical preparations and UV repair skincare
Strict Global Export Quality Control System:
Four-fold strict inspection of heavy metals, pesticides, residual solvents and microbes, compliant with EU, US, Japan & Korea import standards
Full-Chain One-Stop Custom Service:
Free lab samples, ton bulk stock, custom mesh, compound OEM and complete test document delivery
Quality Specifications
| Test Item | Standard Requirement |
|---|---|
| Esculin Content (Pharma HPLC) | ≥98.0% |
| Appearance | Off-white to pale beige acicular crystalline powder |
| Loss on Drying | ≤2.0% |
| Residue on Ignition | ≤0.2% |
| Total Heavy Metals | ≤10ppm |
| Pb≤2ppm, As≤1ppm, Cd≤1ppm, Hg≤0.1ppm | |
| Residual Organic Solvents | Compliant with USP / EP / CP pharmaceutical raw material limits |
| Total Plate Count | ≤500 CFU/g (Strict pharmaceutical standard) |
| Yeast & Mold | ≤50 CFU/g |
| Salmonella, E.coli | Negative |
Application Fields
Natural UV Protection Cosmetics:
0.08%–0.3% for sunscreen serums, repair creams, outdoor soothing sprays
Sensitive Redness Repair Serums:
0.05%–0.18% for anti-redness and post-procedure dressing
Heat-Clearing Anti-Inflammatory Oral TCM Preparations:
5–25mg per serving for tablets, oral liquids and herbal capsules
Venous Soothing Topical Preparations:
0.1%–0.4% for gel & cream relieving venous stasis soreness
Antibacterial Herbal Wash Products:
0.03%–0.1% for soothing body wash and intimate care formulas
Lab Pharmacopoeia Reference Standard:
98% crystal for coumarin quantitative calibration in universities & pharmaceutical labs